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Mickaël Canouil
Curriculum Vitæ
I’m currently working for the Institut Pasteur de Lille at the Inserm U1283 / CNRS UMR 8199 - “Functional (Epi)genomics and Molecular Physiology of Diabetes and Related Diseases” as Head of Biostatistics.
Education
Doctor of Philosophy (Ph.D.) in Biostatistics
University of Lille
Lille, France
Oct. 2014 - Sep. 2017
Master’s Degree in Biostatistics, Bioinformatics and Genomics (Specialised in Biostatistics)
University Claude Bernard Lyon 1
Lyon, France
Sep. 2009 - Jul. 2011
Bachelor’s Degree in Biology (Specialised in Biostatistics)
University Claude Bernard Lyon 1
Lyon, France
Sep. 2006 - Jul. 2009
Professional Experience
Head of Biostatistics (Institut Pasteur de Lille)
Functional (Epi)genomics and Molecular
Physiology of Diabetes and Related Diseases
Inserm U1283 / CNRS UMR 8199 - EGID
(European Genomics Institute for Diabetes)
Lille, France
Jan. 2020 - Present
Activities: Genome-wide association studies, experimental design, -omics data analysis, methodological developments, team management
Head of Biostatistics (Institut Pasteur de Lille)
Laboratory of Integrated Genomics
and Metabolic Diseases Modeling
CNRS UMR 8199 - EGID
(European Genomics Institute for Diabetes)
Lille, France
Oct. 2017 - Dec. 2019
Activities: Genome-wide association studies, experimental design, -omics data analysis, methodological developments, team management
Head of Biostatistics (CNRS)
Laboratory of Integrated Genomics
and Metabolic Diseases Modeling
CNRS UMR 8199 - EGID
(European Genomics Institute for Diabetes)
Lille, France
Jan. 2016 - Sep. 2017
Activities: Genome-wide association studies, experimental design, -omics data analysis, methodological developments, team management
Biostatistician (CNRS)
Laboratory of Integrated Genomics
and Metabolic Diseases Modeling
CNRS UMR 8199 - EGID
(European Genomics Institute for Diabetes)
Lille, France
Sep. 2012 - Dec. 2015
Activities: Genome-wide association studies, experimental design, -omics data analysis, methodological developments
Biostatistician
French Institute of Science and Technology for
Transport, Development and Networks
(IFSTTAR)
UMRESTTE - UMR T9405
Bron, France
Nov. 2011 - Dec. 2011
Activities: Analysis of a mobility and accident study in secondary-school pupils
Biostatistician (Internship)
Hospices Civiles de Lyon
Biostatistics Unit
CNRS UMR 5558
Lyon, France
Jan. 2011 - Jun. 2011
Activities: Development of a Non-Parametric (on Time) Clustering Algorithm for Longitudinal Data
Biostatistician (Internship)
Biometry and Evolutionary Biology laboratory
(LBBE)
CNRS UMR 5558
Lyon, France
Mar. 2010 - Jun. 2010
Activities: Mathematical Modelling of Nosocomial Rotavirus Infections in Pediatric Ward
Workshop Experience (5)
Awards (1)
Funding Allocation SFD-Lilly
“Société Francophone du Diabète”
(SFD)
Bordeaux, France
Mar. 2015
Project: Detection of new genomic variants associated with fasting blood glucose and incidence of type 2 diabetes simultaneously
Oral communications (6)
My Journey To Transparency And Reproducibility
R Lille
Online (Lille, France)
Apr. 2021
My Journey To Transparency And Reproducibility (French)
Min2Rien
Online (Lille, France)
Apr. 2021
“Débuter” avec R en Commençant par le Début … (French)
R Lille
Lille, France
Jan. 2021
Jointly Modelling SNPs With Survival & Longitudinal Trait
A Statistical Seminar Applied on Type 2 Diabetes
(Host: Pr. Paul Franks)
Lund, Sweden
Jan. 2019
Jointly Modelling SNPs With Survival & Longitudinal Trait
Thematic Day “Statistic & Genomic”
of the “Réseau Interdisciplinaire
autour de la Statistique”
(RIS)
Paris, France
Oct. 2018
Longitudinal Genetic Modelling: Revisiting Associations of SNPs Associated With Blood Fasting Glucose in Normoglycemic Individuals
Statistical Methods for Post Genomic Data
(SMPGD)
Lille, France
Feb. 2016
Poster communications (4)
“Variants Génétiques Associés à la Trajectoire de la Glycémie à Jeun et à l’Incidence du Diabète de Type 2: Une Approche par Modèle Joint” (CA-075)
Annual Congress of
“Société Francophone du Diabète”
(SFD)
Lille, France
Mar. 2017
Single Nucleotide Polymorphisms Associated With Fasting Blood Glucose Trajectory And Type 2 Diabetes Incidence: A Joint Modelling Approach
4th Symposium
European Genomic Institute for Diabetes
(EGID)
Lille, France
Nov. 2016
Single Nucleotide Polymorphisms Associated With Fasting Blood Glucose Trajectory And Type 2 Diabetes Incidence: A Joint Modelling Approach
International Genetic Epidemiology Society
(IGES)
Toronto, Canada
Oct. 2016
Application of Joint Models in Genetic Association Studies
International Genetic Epidemiology Society
(IGES)
Baltimore, United-States
Oct. 2015
R Packages (10)
insane: An Interactive Web Application for Quality Control and Analysis of Insulin Secretion from Pancreatic Beta Cells
(As author / creator)
CRAN
Nov. 2020
https://cran.r-project.org/package=insane
https://github.com/mcanouil/insane/
ggpacman: A ‘ggplot2’ and ‘gganimate’ Version of Pac-Man
(As author / creator)
CRAN
May 2020
https://cran.r-project.org/package=ggpacman
https://github.com/mcanouil/ggpacman/
dmapaq: DNA Methylation Arrays Processing And Quality-Control
(As author / creator)
GitHub
Mar. 2020
dgapaq: DNA Genotyping Arrays Processing And Quality-Control
(As author / creator)
GitHub
Mar. 2020
ggnetwork: Geometries to Plot Networks with ‘ggplot2’
(As contributor)
CRAN
Feb. 2020
https://cran.r-project.org/package=ggnetwork
https://github.com/briatte/ggnetwork/
rain: Reference-based Ancestry Inference
(As author / creator)
GitHub
Jan. 2020
MiSTr: Mixed effects Score Test
(As contributor / creator)
GitHub
Nov. 2019
NACHO: NanoString Quality Control Dashboard
(As author / creator)
CRAN
Jun. 2018
https://cran.r-project.org/package=NACHO
https://github.com/mcanouil/NACHO/
clere: Simultaneous Variables Clustering and Regression
(As author)
CRAN
Feb. 2014
https://cran.r-project.org/package=clere
https://github.com/mcanouil/clere/
snpEnrichment: SNPs Enrichment Analysis
(As author / creator)
CRAN
Apr. 2013
https://cran.r-project.org/package=snpEnrichment
https://github.com/mcanouil/snpEnrichment/
Publications (32)
SHP2 Drives Inflammation-triggered Insulin Resistance by Reshaping Tissue Macrophage Populations
Romain Paccoud, Céline Saint-Laurent, Enzo Piccolo, Mylène Tajan, Alizée Dortignac, […], Mickaël Canouil17/33, […], Cédric Dray, Emmanuel L. Gautier, Thomas Edouard, Jean-Philippe Pradère and Armelle Yart
N/A
Apr. 2021
Chromatin 3D Interaction Analysis of the STARD10 Locus Unveils FCHSD2 as a Regulator of Insulin Secretion
Ming Hu, Inês Cebola, Gaelle Carrat, Shuying Jiang, Sameena Nawaz, […], Mickaël Canouil7/18, […], Paul J. Gadue, Benoit Hastoy, Leonardo Alemeida-Souza, Harvey McMahon and Guy A. Rutter
N/A
Feb. 2021
Monogenic Diabetes Characteristics in a Transnational Multicenter Study From Mediterranean Countries
Martine Vaxillaire, Amélie Bonnefond, Stavros Liatis, Leila Ben Salem Hachmi, Aleksandra Jotic, […], Mickaël Canouil11/24, […], Doros Loizou, Nebojsa Lalic, Josanne Vassallo, Michel Marre and Philippe Froguel
N/A
Nov. 2020
Pathogenic Variants in Actionable MODY Genes are Associated with Type 2 Diabetes
Amélie Bonnefond, Mathilde Boissel, Alexandre Bolze, Emmanuelle Durand, Bénédicte Toussaint, […], Martine Vaxillaire, Mickaël Canouil24/27, Nicole L. Washington, Joseph J. Grzymski and Philippe Froguel
N/A
Oct. 2020
Gene-Educational Attainment Interactions in a Multi-Ancestry Genome-Wide Meta-Analysis Identify Novel Blood Pressure Loci
Lifelines Cohort Study, Lisa de las Fuentes, Yun Ju Sung, Raymond Noordam, Thomas Winkler, […], Mickaël Canouil75/223, […], Paul Elliott, Patricia B. Munroe, Paul W. Franks, Dabeeru C. Rao and Myriam Fornage
N/A
May 2020
General Regression Model: A “Model-Free” Association Test for Quantitative Traits Allowing to Test for the Underlying Genetic Model
Emilie Gloaguen, Marie-Hélène Dizier, Mathilde Boissel, Ghislain Rocheleau, Mickaël Canouil5/11, […], Jean Tichet, Ronan Roussel, Cécile Julier, Beverley Balkau and Flavie Mathieu
N/A
Dec. 2019
Loss-of-Function Mutations in MRAP2 Are Pathogenic in Hyperphagic Obesity with Hyperglycemia and Hypertension
Morgane Baron, Julie Maillet, Marlène Huyvaert, Aurélie Dechaume, Raphaël Boutry, […], Mehdi Derhourhi, Stefan Gaget, Mickaël Canouil29/31, Philippe Froguel and Amélie Bonnefond
N/A
Nov. 2019
NACHO: An R package for Quality Control of NanoString nCounter Data
Mickaël Canouil, Gerard A Bouland, Amélie Bonnefond, Philippe Froguel, Leen M ’t Hart and Roderick C Slieker
N/A
Aug. 2019
The Expression of Genes in Top Obesity-Associated Loci Is Enriched in Insula and Substantia Nigra Brain Regions Involved in Addiction and Reward
Fatou K. Ndiaye, Marlène Huyvaert, Ana Ortalli, Mickaël Canouil4/17, Cécile Lecoeur, […], Michel Marre, Ronan Roussel, Beverley Balkau, Philippe Froguel and Amélie Bonnefond
N/A
Aug. 2019
A Trans-Ancestral Meta-Analysis of Genome-Wide Association Studies Reveals Loci Associated with Childhood Obesity
Jonathan P. Bradfield, Suzanne Vogelezang, Janine F. Felix, Alessandra Chesi, Øyvind Helgeland, […], Mickaël Canouil41/99, […], Nicholas J. Timpson, Stefan Johansson, Hakon Hakonarson, Vincent W. V. Jaddoe and Struan F. A. Grant
N/A
Jul. 2019
Genome-Wide Association Study of Change in Fasting Glucose Over Time in 13,807 Non-Diabetic European Ancestry Individuals
Ching-Ti Liu, Jordi Merino, Denis Rybin, Daniel DiCorpo, Kelly S. Benke, […], Mickaël Canouil7/50, […], Inês Barroso, Inga Prokopenko, Josée Dupuis, James B. Meigs and Nabila Bouatia-Naji
N/A
Jul. 2019
A Catalog of Genetic Loci Associated with Kidney Function From Analyses of a Million Individuals
Matthias Wuttke, Yong Li, Man Li, Karsten B. Sieber, Mary F. Feitosa, […], Mickaël Canouil51/327, […], Iris M. Heid, Markus Scholz, Alexander Teumer, Anna Köttgen and Cristian Pattaro
N/A
Jun. 2019
A Multi-Ancestry Genome-Wide Study Incorporating Gene-Smoking Interactions Identifies Multiple New Loci for Pulse Pressure and Mean Arterial Pressure
Yun Ju Sung, Lisa de las Fuentes, Thomas W. Winkler, Daniel I. Chasman, Amy R. Bentley, […], Mickaël Canouil95/282, […], Mark J. Caulfield, W. James Gauderman, Patricia B. Munroe, Dabeeru C. Rao and Alanna C. Morrison
N/A
Apr. 2019
Multi-Ancestry Genome-Wide Gene–Smoking Interaction Study of 387,272 Individuals Identifies New Loci Associated with Serum Lipids
Amy R. Bentley, Yun J. Sung, Michael R. Brown, Thomas W. Winkler, Aldi T. Kraja, […], Mickaël Canouil97/301, […], Patricia B. Munroe, Alanna C. Morrison, Dabeeru C. Rao, Charles N. Rotimi and L. Adrienne Cupples
N/A
Apr. 2019
Laser Capture Microdissection of Human Pancreatic Islets Reveals Novel eQTLs Associated with Type 2 Diabetes
Amna Khamis, Mickaël Canouil2/20, Afshan Siddiq, Hutokshi Crouch, Mario Falchi, […], Mark Ibberson, Amelie Bonnefond, Piero Marchetti, Michele Solimena and Philippe Froguel
N/A
Mar. 2019
Multi-Ancestry Genome-Wide Association Study of Lipid Levels Incorporating Gene-Alcohol Interactions
Paul S. de Vries, Michael R. Brown, Amy R. Bentley, Yun J. Sung, Thomas W. Winkler, […], Mickaël Canouil81/266, […], Kenneth Rice, Daniel I. Chasman, L. Adrienne Cupples, Dabeeru C. Rao and Alanna C. Morrison
N/A
Jan. 2019
Multi-Ancestry Study of Blood Lipid Levels Identifies Four Loci Interacting with Physical Activity
Lifelines Cohort Study, Tuomas O. Kilpeläinen, Amy R. Bentley, Raymond Noordam, Yun Ju Sung, […], Mickaël Canouil75/230, […], L. Adrienne Cupples, Charles N. Rotimi, Alanna C. Morrison, Dabeeru C. Rao and Ruth J. F. Loos
N/A
Jan. 2019
Fine-Mapping Type 2 Diabetes Loci to Single-Variant Resolution Using High-Density Imputation and Islet-Specific Epigenome Maps
Anubha Mahajan, Daniel Taliun, Matthias Thurner, Neil R. Robertson, Jason M. Torres, […], Mickaël Canouil35/115, […], Kari Stefansson, Anna L. Gloyn, Andrew P. Morris, Michael Boehnke and Mark I. McCarthy
N/A
Oct. 2018
Type 2 Diabetes–Associated Variants of the MT2 Melatonin Receptor Affect Distinct Modes of Signaling
Angeliki Karamitri, Bianca Plouffe, Amélie Bonnefond, Min Chen, Jonathan Gallion, […], Mickaël Canouil9/17, […], Viktoria Lukasheva, Olivier Lichtarge, Philippe Froguel, Michel Bouvier and Ralf Jockers
N/A
Aug. 2018
Novel Genetic Associations for Blood Pressure Identified via Gene-Alcohol Interaction in up to 570K Individuals Across Multiple Ancestries
Mary F. Feitosa, Aldi T. Kraja, Daniel I. Chasman, Yun J. Sung, Thomas W. Winkler, […], Mickaël Canouil87/274, […], Mark J. Caulfield, Patricia B. Munroe, Dabeeru C. Rao, Michael A. Province and Daniel Levy
N/A
Jun. 2018
Jointly Modelling Single Nucleotide Polymorphisms with Longitudinal and Time-to-Event Trait: An Application to Type 2 Diabetes and Fasting Plasma Glucose
Mickaël Canouil, Beverley Balkau, Ronan Roussel, Philippe Froguel and Ghislain Rocheleau
N/A
Jun. 2018
Increased Hepatic PDGF-AA Signaling Mediates Liver Insulin Resistance in Obesity Associated Type 2 Diabetes
Amar Abderrahmani, Loïc Yengo, Robert Caiazzo, Mickaël Canouil4/38, Stéphane Cauchi, […], Clemens Schafmayer, Jochen Hampe, Amélie Bonnefond, François Pattou and Philippe Froguel
N/A
May 2018
Refining the Accuracy of Validated Target Identification Through Coding Variant Fine-Mapping in Type 2 Diabetes
Anubha Mahajan, Jennifer Wessel, Sara M. Willems, Wei Zhao, Neil R. Robertson, […], Mickaël Canouil68/243, […], Michael Boehnke, Danish Saleheen, Andrew P. Morris, Jerome I. Rotter and Mark I. McCarthy
N/A
Apr. 2018
A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure
Yun J. Sung, Thomas W. Winkler, Lisa de Las Fuentes, Amy R. Bentley, Michael R. Brown, […], Mickaël Canouil94/301, […], Patricia B. Munroe, Alanna C. Morrison, L. Adrienne Cupples, Dabeeru C. Rao and Daniel I. Chasman
N/A
Mar. 2018
Low-Dose Exposure to Bisphenols A, F and S of Human Primary Adipocyte Impacts Coding and Non-Coding RNA Profiles
Marie Verbanck, Mickaël Canouil, Audrey Leloire, Véronique Dhennin, Xavier Coumoul, Loïc Yengo, Philippe Froguel and Odile Poulain-Godefroy
N/A
Jun. 2017
Expression and Functional Assessment of Candidate Type 2 Diabetes Susceptibility Genes Identify Four New Genes Contributing to Human Insulin Secretion
Fatou K. Ndiaye, Ana Ortalli, Mickaël Canouil3/22, Marlène Huyvaert, Clara Salazar-Cardozo, […], Piero Marchetti, François Pattou, Amar Abderrahmani, Philippe Froguel and Amélie Bonnefond
N/A
Jun. 2017
Relationship Between Salivary/Pancreatic Amylase and Body Mass Index: A Systems Biology Approach
Amélie Bonnefond, Loïc Yengo, Aurélie Dechaume, Mickaël Canouil4/20, Maxime Castelain, […], Beverley Balkau, Michel Marre, François Pattou, Thierry Brousseau and Philippe Froguel
N/A
Feb. 2017
Decreased STARD10 Expression Is Associated with Defective Insulin Secretion in Humans and Mice
Gaelle R. Carrat, Ming Hu, Marie-Sophie Nguyen-Tu, Pauline Chabosseau, Kyle J. Gaulton, […], Mickaël Canouil10/26, […], Anna L. Gloyn, Philippe Froguel, Michele Solimena, Mark I. McCarthy and Guy A. Rutter
N/A
Feb. 2017
Hepatic DPP4 DNA Methylation Associates with Fatty Liver
Christian Baumeier, Sophie Saussenthaler, Anne Kammel, Markus Jähnert, Luisa Schlüter, […], Mickaël Canouil7/17, […], Jussi Pihlajamäki, Charlotte Ling, Philippe Froguel, Annette Schürmann and Robert W. Schwenk
N/A
Jan. 2017
Variable Clustering in High-Dimensional Linear Regression: The R Package
Loïc Yengo, Julien Jacques, Christophe Biernacki and Mickaël Canouil
N/A
Apr. 2016