Curriculum Vitæ

I’m currently working for the Institut Pasteur de Lille at the Inserm U1283 / CNRS UMR 8199 - “Functional (Epi)genomics and Molecular Physiology of Diabetes and Related Diseases” as Head of Biostatistics.

Doctor of Philosophy (Ph.D.) in Biostatistics

University of Lille

Lille, France

Oct. 2014 - Sep. 2017

Master’s Degree in Biostatistics, Bioinformatics and Genomics (Specialised in Biostatistics)

University Claude Bernard Lyon 1

Lyon, France

Sep. 2009 - Jul. 2011

Bachelor’s Degree in Biology (Specialised in Biostatistics)

University Claude Bernard Lyon 1

Lyon, France

Sep. 2006 - Jul. 2009

Head of Biostatistics (Institut Pasteur de Lille)

Functional (Epi)genomics and Molecular
Physiology of Diabetes and Related Diseases
Inserm U1283 / CNRS UMR 8199 - EGID
(European Genomics Institute for Diabetes)

Lille, France

Jan. 2020 - Present

Activities: Genome-wide association studies, experimental design, -omics data analysis, methodological developments, team management

Head of Biostatistics (Institut Pasteur de Lille)

Laboratory of Integrated Genomics
and Metabolic Diseases Modeling
CNRS UMR 8199 - EGID
(European Genomics Institute for Diabetes)

Lille, France

Oct. 2017 - Dec. 2019

Activities: Genome-wide association studies, experimental design, -omics data analysis, methodological developments, team management

Head of Biostatistics (CNRS)

Laboratory of Integrated Genomics
and Metabolic Diseases Modeling
CNRS UMR 8199 - EGID
(European Genomics Institute for Diabetes)

Lille, France

Jan. 2016 - Sep. 2017

Activities: Genome-wide association studies, experimental design, -omics data analysis, methodological developments, team management

Biostatistician (CNRS)

Laboratory of Integrated Genomics
and Metabolic Diseases Modeling
CNRS UMR 8199 - EGID
(European Genomics Institute for Diabetes)

Lille, France

Sep. 2012 - Dec. 2015

Activities: Genome-wide association studies, experimental design, -omics data analysis, methodological developments

Biostatistician

French Institute of Science and Technology for
Transport, Development and Networks
(IFSTTAR)
UMRESTTE - UMR T9405

Bron, France

Nov. 2011 - Dec. 2011

Activities: Analysis of a mobility and accident study in secondary-school pupils

Biostatistician (Internship)

Hospices Civiles de Lyon
Biostatistics Unit
CNRS UMR 5558

Lyon, France

Jan. 2011 - Jun. 2011

Activities: Development of a Non-Parametric (on Time) Clustering Algorithm for Longitudinal Data

Biostatistician (Internship)

Biometry and Evolutionary Biology laboratory
(LBBE)
CNRS UMR 5558

Lyon, France

Mar. 2010 - Jun. 2010

Activities: Mathematical Modelling of Nosocomial Rotavirus Infections in Pediatric Ward

R Advanced

Half-day workshop (in French)

Lille, France

Nov. 2020

ggplot2

Half-day workshop (in French)

Lille, France

Oct. 2020

R Packages

Thirty minutes overview (in English

Lille, France

Feb. 2020

Shiny: First Steps

One-day workshop (in French)

Lille, France

Nov. 2019

R and Databases

Two-days workshop (in French)

Lille, France

May 2018

Funding Allocation SFD-Lilly

“Société Francophone du Diabète”
(SFD)

Bordeaux, France

Mar. 2015

Project: Detection of new genomic variants associated with fasting blood glucose and incidence of type 2 diabetes simultaneously

“Variants Génétiques Associés à la Trajectoire de la Glycémie à Jeun et à l’Incidence du Diabète de Type 2: Une Approche par Modèle Joint” (CA-075)

Annual Congress of
“Société Francophone du Diabète”
(SFD)

Lille, France

Mar. 2017

Single Nucleotide Polymorphisms Associated With Fasting Blood Glucose Trajectory And Type 2 Diabetes Incidence: A Joint Modelling Approach

4th Symposium
European Genomic Institute for Diabetes
(EGID)

Lille, France

Nov. 2016

Single Nucleotide Polymorphisms Associated With Fasting Blood Glucose Trajectory And Type 2 Diabetes Incidence: A Joint Modelling Approach

International Genetic Epidemiology Society
(IGES)

Toronto, Canada

Oct. 2016

Application of Joint Models in Genetic Association Studies

International Genetic Epidemiology Society
(IGES)

Baltimore, United-States

Oct. 2015

insane: An Interactive Web Application for Quality Control and Analysis of Insulin Secretion from Pancreatic Beta Cells

(As author / creator)

CRAN

Nov. 2020

https://cran.r-project.org/package=insane
https://github.com/mcanouil/insane/

ggpacman: A ‘ggplot2’ and ‘gganimate’ Version of Pac-Man

(As author / creator)

CRAN

May 2020

https://cran.r-project.org/package=ggpacman
https://github.com/mcanouil/ggpacman/

dmapaq: DNA Methylation Arrays Processing And Quality-Control

(As author / creator)

GitHub

Mar. 2020

https://github.com/umr1283/dmapaq/

dgapaq: DNA Genotyping Arrays Processing And Quality-Control

(As author / creator)

GitHub

Mar. 2020

https://github.com/umr1283/dgapaq/

ggnetwork: Geometries to Plot Networks with ‘ggplot2’

(As contributor)

CRAN

Feb. 2020

https://cran.r-project.org/package=ggnetwork
https://github.com/briatte/ggnetwork/

rain: Reference-based Ancestry Inference

(As author / creator)

GitHub

Jan. 2020

https://github.com/umr1283/rain/

MiSTr: Mixed effects Score Test

(As contributor / creator)

GitHub

Nov. 2019

https://github.com/mcanouil/MiSTr/

NACHO: NanoString Quality Control Dashboard

(As author / creator)

CRAN

Jun. 2018

https://cran.r-project.org/package=NACHO
https://github.com/mcanouil/NACHO/

clere: Simultaneous Variables Clustering and Regression

(As author)

CRAN

Feb. 2014

https://cran.r-project.org/package=clere
https://github.com/mcanouil/clere/

snpEnrichment: SNPs Enrichment Analysis

(As author / creator)

CRAN

Apr. 2013

https://cran.r-project.org/package=snpEnrichment
https://github.com/mcanouil/snpEnrichment/

SHP2 Drives Inflammation-triggered Insulin Resistance by Reshaping Tissue Macrophage Populations

Romain Paccoud, Céline Saint-Laurent, Enzo Piccolo, Mylène Tajan, Alizée Dortignac, […], Mickaël Canouil^17/33, […], Cédric Dray, Emmanuel L. Gautier, Thomas Edouard, Jean-Philippe Pradère and Armelle Yart

N/A

Apr. 2021

Chromatin 3D Interaction Analysis of the STARD10 Locus Unveils FCHSD2 as a Regulator of Insulin Secretion

Ming Hu, Inês Cebola, Gaelle Carrat, Shuying Jiang, Sameena Nawaz, […], Mickaël Canouil^7/18, […], Paul J. Gadue, Benoit Hastoy, Leonardo Alemeida-Souza, Harvey McMahon and Guy A. Rutter

N/A

Feb. 2021

Persistent or Transient Human β Cell Dysfunction Induced by Metabolic Stress: Specific Signatures and Shared Gene Expression with Type 2 Diabetes

Lorella Marselli, Anthony Piron, Mara Suleiman, Maikel L. Colli, Xiaoyan Yi, […], Mickaël Canouil^32/36, Philippe Froguel, Decio L. Eizirik, Miriam Cnop and Piero Marchetti

N/A

Dec. 2020

Monogenic Diabetes Characteristics in a Transnational Multicenter Study From Mediterranean Countries

Martine Vaxillaire, Amélie Bonnefond, Stavros Liatis, Leila Ben Salem Hachmi, Aleksandra Jotic, […], Mickaël Canouil^11/24, […], Doros Loizou, Nebojsa Lalic, Josanne Vassallo, Michel Marre and Philippe Froguel

N/A

Nov. 2020

Pathogenic Variants in Actionable MODY Genes are Associated with Type 2 Diabetes

Amélie Bonnefond, Mathilde Boissel, Alexandre Bolze, Emmanuelle Durand, Bénédicte Toussaint, […], Martine Vaxillaire, Mickaël Canouil^24/27, Nicole L. Washington, Joseph J. Grzymski and Philippe Froguel

N/A

Oct. 2020

Histone Deacetylase 9 Promoter Hypomethylation Associated with Adipocyte Dysfunction is a Statin-Related Metabolic Effect

Amna Khamis, Raphael Boutry, Mickaël Canouil, Sumi Mathew, Stephane Lobbens, Hutokshi Crouch, Toby Andrew, Amar Abderrahmani, Filippo Tamanini and Philippe Froguel

N/A

May 2020

Gene-Educational Attainment Interactions in a Multi-Ancestry Genome-Wide Meta-Analysis Identify Novel Blood Pressure Loci

Lifelines Cohort Study, Lisa de las Fuentes, Yun Ju Sung, Raymond Noordam, Thomas Winkler, […], Mickaël Canouil^75/223, […], Paul Elliott, Patricia B. Munroe, Paul W. Franks, Dabeeru C. Rao and Myriam Fornage

N/A

May 2020

General Regression Model: A “Model-Free” Association Test for Quantitative Traits Allowing to Test for the Underlying Genetic Model

Emilie Gloaguen, Marie-Hélène Dizier, Mathilde Boissel, Ghislain Rocheleau, Mickaël Canouil^5/11, […], Jean Tichet, Ronan Roussel, Cécile Julier, Beverley Balkau and Flavie Mathieu

N/A

Dec. 2019

Loss-of-Function Mutations in MRAP2 Are Pathogenic in Hyperphagic Obesity with Hyperglycemia and Hypertension

Morgane Baron, Julie Maillet, Marlène Huyvaert, Aurélie Dechaume, Raphaël Boutry, […], Mehdi Derhourhi, Stefan Gaget, Mickaël Canouil^29/31, Philippe Froguel and Amélie Bonnefond

N/A

Nov. 2019

NACHO: An R package for Quality Control of NanoString nCounter Data

Mickaël Canouil, Gerard A Bouland, Amélie Bonnefond, Philippe Froguel, Leen M ’t Hart and Roderick C Slieker

N/A

Aug. 2019

The Expression of Genes in Top Obesity-Associated Loci Is Enriched in Insula and Substantia Nigra Brain Regions Involved in Addiction and Reward

Fatou K. Ndiaye, Marlène Huyvaert, Ana Ortalli, Mickaël Canouil^4/17, Cécile Lecoeur, […], Michel Marre, Ronan Roussel, Beverley Balkau, Philippe Froguel and Amélie Bonnefond

N/A

Aug. 2019

A Trans-Ancestral Meta-Analysis of Genome-Wide Association Studies Reveals Loci Associated with Childhood Obesity

Jonathan P. Bradfield, Suzanne Vogelezang, Janine F. Felix, Alessandra Chesi, Øyvind Helgeland, […], Mickaël Canouil^41/99, […], Nicholas J. Timpson, Stefan Johansson, Hakon Hakonarson, Vincent W. V. Jaddoe and Struan F. A. Grant

N/A

Jul. 2019

Genome-Wide Association Study of Change in Fasting Glucose Over Time in 13,807 Non-Diabetic European Ancestry Individuals

Ching-Ti Liu, Jordi Merino, Denis Rybin, Daniel DiCorpo, Kelly S. Benke, […], Mickaël Canouil^7/50, […], Inês Barroso, Inga Prokopenko, Josée Dupuis, James B. Meigs and Nabila Bouatia-Naji

N/A

Jul. 2019

A Catalog of Genetic Loci Associated with Kidney Function From Analyses of a Million Individuals

Matthias Wuttke, Yong Li, Man Li, Karsten B. Sieber, Mary F. Feitosa, […], Mickaël Canouil^51/327, […], Iris M. Heid, Markus Scholz, Alexander Teumer, Anna Köttgen and Cristian Pattaro

N/A

Jun. 2019

A Multi-Ancestry Genome-Wide Study Incorporating Gene-Smoking Interactions Identifies Multiple New Loci for Pulse Pressure and Mean Arterial Pressure

Yun Ju Sung, Lisa de las Fuentes, Thomas W. Winkler, Daniel I. Chasman, Amy R. Bentley, […], Mickaël Canouil^95/282, […], Mark J. Caulfield, W. James Gauderman, Patricia B. Munroe, Dabeeru C. Rao and Alanna C. Morrison

N/A

Apr. 2019

Multi-Ancestry Genome-Wide Gene–Smoking Interaction Study of 387,272 Individuals Identifies New Loci Associated with Serum Lipids

Amy R. Bentley, Yun J. Sung, Michael R. Brown, Thomas W. Winkler, Aldi T. Kraja, […], Mickaël Canouil^97/301, […], Patricia B. Munroe, Alanna C. Morrison, Dabeeru C. Rao, Charles N. Rotimi and L. Adrienne Cupples

N/A

Apr. 2019

Laser Capture Microdissection of Human Pancreatic Islets Reveals Novel eQTLs Associated with Type 2 Diabetes

Amna Khamis, Mickaël Canouil^2/20, Afshan Siddiq, Hutokshi Crouch, Mario Falchi, […], Mark Ibberson, Amelie Bonnefond, Piero Marchetti, Michele Solimena and Philippe Froguel

N/A

Mar. 2019

Multi-Ancestry Genome-Wide Association Study of Lipid Levels Incorporating Gene-Alcohol Interactions

Paul S. de Vries, Michael R. Brown, Amy R. Bentley, Yun J. Sung, Thomas W. Winkler, […], Mickaël Canouil^81/266, […], Kenneth Rice, Daniel I. Chasman, L. Adrienne Cupples, Dabeeru C. Rao and Alanna C. Morrison

N/A

Jan. 2019

Multi-Ancestry Study of Blood Lipid Levels Identifies Four Loci Interacting with Physical Activity

Lifelines Cohort Study, Tuomas O. Kilpeläinen, Amy R. Bentley, Raymond Noordam, Yun Ju Sung, […], Mickaël Canouil^75/230, […], L. Adrienne Cupples, Charles N. Rotimi, Alanna C. Morrison, Dabeeru C. Rao and Ruth J. F. Loos

N/A

Jan. 2019

Fine-Mapping Type 2 Diabetes Loci to Single-Variant Resolution Using High-Density Imputation and Islet-Specific Epigenome Maps

Anubha Mahajan, Daniel Taliun, Matthias Thurner, Neil R. Robertson, Jason M. Torres, […], Mickaël Canouil^35/115, […], Kari Stefansson, Anna L. Gloyn, Andrew P. Morris, Michael Boehnke and Mark I. McCarthy

N/A

Oct. 2018

Type 2 Diabetes–Associated Variants of the MT2 Melatonin Receptor Affect Distinct Modes of Signaling

Angeliki Karamitri, Bianca Plouffe, Amélie Bonnefond, Min Chen, Jonathan Gallion, […], Mickaël Canouil^9/17, […], Viktoria Lukasheva, Olivier Lichtarge, Philippe Froguel, Michel Bouvier and Ralf Jockers

N/A

Aug. 2018

Novel Genetic Associations for Blood Pressure Identified via Gene-Alcohol Interaction in up to 570K Individuals Across Multiple Ancestries

Mary F. Feitosa, Aldi T. Kraja, Daniel I. Chasman, Yun J. Sung, Thomas W. Winkler, […], Mickaël Canouil^87/274, […], Mark J. Caulfield, Patricia B. Munroe, Dabeeru C. Rao, Michael A. Province and Daniel Levy

N/A

Jun. 2018

Jointly Modelling Single Nucleotide Polymorphisms with Longitudinal and Time-to-Event Trait: An Application to Type 2 Diabetes and Fasting Plasma Glucose

Mickaël Canouil, Beverley Balkau, Ronan Roussel, Philippe Froguel and Ghislain Rocheleau

N/A

Jun. 2018

Increased Hepatic PDGF-AA Signaling Mediates Liver Insulin Resistance in Obesity Associated Type 2 Diabetes

Amar Abderrahmani, Loïc Yengo, Robert Caiazzo, Mickaël Canouil^4/38, Stéphane Cauchi, […], Clemens Schafmayer, Jochen Hampe, Amélie Bonnefond, François Pattou and Philippe Froguel

N/A

May 2018

Refining the Accuracy of Validated Target Identification Through Coding Variant Fine-Mapping in Type 2 Diabetes

Anubha Mahajan, Jennifer Wessel, Sara M. Willems, Wei Zhao, Neil R. Robertson, […], Mickaël Canouil^68/243, […], Michael Boehnke, Danish Saleheen, Andrew P. Morris, Jerome I. Rotter and Mark I. McCarthy

N/A

Apr. 2018

A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure

Yun J. Sung, Thomas W. Winkler, Lisa de Las Fuentes, Amy R. Bentley, Michael R. Brown, […], Mickaël Canouil^94/301, […], Patricia B. Munroe, Alanna C. Morrison, L. Adrienne Cupples, Dabeeru C. Rao and Daniel I. Chasman

N/A

Mar. 2018

Low-Dose Exposure to Bisphenols A, F and S of Human Primary Adipocyte Impacts Coding and Non-Coding RNA Profiles

Marie Verbanck, Mickaël Canouil, Audrey Leloire, Véronique Dhennin, Xavier Coumoul, Loïc Yengo, Philippe Froguel and Odile Poulain-Godefroy

N/A

Jun. 2017

Expression and Functional Assessment of Candidate Type 2 Diabetes Susceptibility Genes Identify Four New Genes Contributing to Human Insulin Secretion

Fatou K. Ndiaye, Ana Ortalli, Mickaël Canouil^3/22, Marlène Huyvaert, Clara Salazar-Cardozo, […], Piero Marchetti, François Pattou, Amar Abderrahmani, Philippe Froguel and Amélie Bonnefond

N/A

Jun. 2017

Relationship Between Salivary/Pancreatic Amylase and Body Mass Index: A Systems Biology Approach

Amélie Bonnefond, Loïc Yengo, Aurélie Dechaume, Mickaël Canouil^4/20, Maxime Castelain, […], Beverley Balkau, Michel Marre, François Pattou, Thierry Brousseau and Philippe Froguel

N/A

Feb. 2017

Decreased STARD10 Expression Is Associated with Defective Insulin Secretion in Humans and Mice

Gaelle R. Carrat, Ming Hu, Marie-Sophie Nguyen-Tu, Pauline Chabosseau, Kyle J. Gaulton, […], Mickaël Canouil^10/26, […], Anna L. Gloyn, Philippe Froguel, Michele Solimena, Mark I. McCarthy and Guy A. Rutter

N/A

Feb. 2017

Hepatic DPP4 DNA Methylation Associates with Fatty Liver

Christian Baumeier, Sophie Saussenthaler, Anne Kammel, Markus Jähnert, Luisa Schlüter, […], Mickaël Canouil^7/17, […], Jussi Pihlajamäki, Charlotte Ling, Philippe Froguel, Annette Schürmann and Robert W. Schwenk

N/A

Jan. 2017

Variable Clustering in High-Dimensional Linear Regression: The R Package

Loïc Yengo, Julien Jacques, Christophe Biernacki and Mickaël Canouil

N/A

Apr. 2016